Use High Grade Medical Supplies, then restore the Pal’s SAN before returning it to the same workload.
What cures Depressed?
The base HUD may describe the Pal as extremely unhealthy due to neglect.
Treat it cleanly
- 01
Use High Grade Medical Supplies
This is the matching tier for Weakened and Depressed. Condition medicine is tier-specific, so do not assume a more expensive supply cures every lower-tier ailment.
- 02
Administer it manually or stock the rack
For a quick manual cure, add the Pal to your party and use the medicine from your inventory. At a base, a reachable Medicine Rack stocked with the correct supply lets the affected Pal collect it automatically.
- 03
Restore SAN before redeploying
The medicine clears the condition, but it does not repair the routine that caused it. Let the Pal recover in the Palbox or a Hot Spring, then check food, beds, paths, and workload before putting it back on shift.
Why it happens
Low SAN after long work shifts, harsh Monitoring Stand settings, or too little recovery time.
A blocked route to the Feed Box, bed, Hot Spring, or Medicine Rack.
Food that restores too little SAN for the base workload.
Stop it coming back
Keep one reachable bed per deployed Pal and leave wide, uncluttered routes around base facilities.
Stock the first Feed Box slot with a meal that restores SAN, not just satiety.
Build enough Hot Springs for the size of the workforce and ease aggressive work settings when SAN trends down.
Use a staffed Clinic or Ancient Clinic to slow SAN loss and suppress illness in demanding bases.
For busy 1.0 bases: a staffed Clinic or Ancient Clinic reduces SAN depletion and suppresses illness. Pair it with a stocked Medicine Rack so prevention and treatment both happen inside the normal work loop.
Frequently asked questions
What medicine cures Depressed in Palworld?
High Grade Medical Supplies cures Depressed. It is a condition cure, not an HP-restoring medicine.
Can Depressed go away in the Palbox?
It can recover while stored, but the timing varies. The matching medicine is the immediate and predictable treatment.
What else does High Grade Medical Supplies cure?
High Grade Medical Supplies also treats Weakened. Keep the matching tier in a Medicine Rack if the condition appears repeatedly.
Why did Depressed come back after treatment?
Recurring ailments usually mean SAN, food access, pathing, beds, Hot Springs, or workload still need attention. Cure the symptom, then fix the base routine.